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visually I find the body background a bit too pink, perhaps try a different shade than the twitter sidebar.
Body could also do with a bit more white space and perhaps bump the font size up a touch. Theres not a lot of content so you can afford to give it some space which will allow it to stand out more and increase readability. The top left corner of the content can overlap the floral image in the top left corner which doesn't look nice.
Use a jquery works well, one thing I'd suggest adding is have the portfolio images popup using a lightbox effect instead of opening them on a new page. Opening a new page for the image just ruins the one page site effect.
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Creative Nuts commented:just mouseover on portfolio images, and you will see larger view.
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Mick Barry commented:Yes I saw (and liked) the mouseover. I was referring to when the image was clicked on. If the mouseover is enough then you could make the images not clickable.
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try using the same lighter rounded box that you use for tweets for the body content