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I love the clean look of this design.
The open space is great and provides some good definition. That said, here are my thoughts:
The spacing between the navigation items and the login prompt, as well as the spacing between the navigation and the end of the topmost gradient box seems to be overkill in my opinion.
The slideshow area, while very open, has the sense of someone just plunking it down since it does not have any container element. I like how hulu.com solves this problem with their slideshow. Because this is so free floating on this design it looks like it could use some more attention.
Rounded corners theme: for some containers you have rounded corners, for some you have square corners, this might be intentional, but I would try to keep a consistent theme.
Overall great design.

Thanks for your feedback - very objective! I will take that to the next version.