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I'm a frequent visitor of the CURE's current site, so I'm a fan of the organization and feel that your design does this great organization justice...well done!
Two usability suggestions:
1) Can you make the "Donate Now" button in the global nav a different color from the green buttons used throughout? That's one of the primary motives of this redesign, and I feel like it gets lost a little being in a low visibility area. Can you make the donate button the darker green from the "CURE" text in the logo?
2) The text, "healing changes everything." looks like a link to me. I think you'll get a lot of users trying to click there. It's a great tag, I think that maybe italicizing it or something to make it pop would give it a better effect while not appearing to be clickable. It will also make the "donate now" button jump out being a different color.
3) The 4 options, "Give a child hope and healing, Sign a Cast. Help a child walk., etc., etc.". They don't appear to me as 4 simple ways that I can make a difference to the organization. It might work a little better if they had numbers in front of them (IE - 1. Give a child hope and healing 2. Sign a Cast. Help a child walk., etc.)
4) The donate option doesn't appear again until the first footer. It falls below the fold. Can you reiterate it creatively in the main content section?
Great work - can't wait to see the finished product.

Hi Josh! You must be Stephen's family (son in law?). He told me you saw the last version I posted.
Thanks for your suggestions, I'm certainly open to them and willing to try different things out. These are some of the most thoughtful and helpful responses I've received.
Here are some responses...
1) Good thought, I'll try out the primary green as you've suggested.
2) What is making it look like a link to you, the shadow underneath the text? Is it making it look like an underline?
3) They really are not supposed to be sequetial in any fashion. The purpose for that content is going to be to feature our monthly appeals content, or any other current campaigns that are going on. So it's not really going to be sequential.
4) There is a donate option within the first content piece (by the way those four are just mock content for now, likely some or most of them will be used at some point, but those will probably be replaced with content related to whatever our current campaigns are). But you will see the first, second and third slides all have calls to action that can be clicked.
One thing we are trying to avoid is making the donate features too obnoxious. My goal is to have them clear and easy to find, without having too many donate options all over the place. We have to be careful that visitors don't feel like all we want from them is their money. Part of how we are trying to accomplish that is by giving plenty of content to them, without having to give an equal number of ask buttons.
Thanks alot for your input!!